A recent study presented at the American Heart Association (AHA) Scientific Sessions has sparked public concern over the long-term safety of melatonin, one of the most commonly used sleep aids in the UK and US. While melatonin is generally viewed as safe for short-term insomnia, this new analysis suggests there may be more to the story when it comes to long-term use.
What the New Study Did 🔍
The study examined electronic health records of roughly 130,000 adults diagnosed with sleep problems. The participants were split into two major groups:
Melatonin users: those who took melatonin for at least 1 year
Non-users: individuals with sleep problems who did not take melatonin
The data was reviewed over a five-year period, making it one of the largest melatonin-related analyses attempted so far.
Key Findings Raising Questions ⚠️
According to the abstract:
1. Heart Failure Hospitalization
Long-term melatonin users were:
3× more likely to be hospitalized with heart failure
(19% among users vs 6.6% among non-users)
2. Higher Rates of Heart Failure Diagnosis
Beyond hospitalization, melatonin users showed:
Increased risk of being diagnosed with heart failure
Higher risk of death from any cause
These findings triggered widespread concern because melatonin is widely believed to be “natural” and harmless.
The Most Important Question No One Has Answered Yet
Why were some people prescribed melatonin while others were not?
This matters because:
People with more severe sleep problems may also have underlying health issues, including heart conditions.
Doctors typically reserve melatonin prescriptions for people who already struggle with persistent insomnia or have conditions like ADHD.
Severe insomnia itself is linked to higher risks of:
high blood pressure
heart disease
metabolic disorders
depression and anxiety
In other words, melatonin might not be the cause — it may simply be a marker indicating that the person already had poorer health.
Conflicting Evidence: Many Previous Studies Suggest Melatonin Helps the Heart Interestingly, past research suggests the opposite of this new study:
Some studies show melatonin may:
Reduce inflammation
Improve sleep quality (which helps the heart)
Improve heart function in people with heart failure
Reduce oxidative stress
Act as a protective antioxidant
Other studies found:
Melatonin improved symptoms in heart failure patients
It was safe as a complementary therapy
This contradiction is why the new findings must be interpreted very cautiously.
🩺 Expert Takeaway
While the study raises important questions, experts emphasize:
It does NOT prove melatonin causes heart failure.
It only shows an association, and many other factors may explain the results.
Doctors currently advise:
Starting with lifestyle changes and sleep hygiene
Using melatonin only short-term when needed
Avoiding panic until more rigorous research is published
The AHA findings are more of a warning flag than a verdict.
Bottom Line
The new study raises concerns about potential long-term risks of melatonin, but the evidence is too incomplete to draw firm conclusions. Without dosage data, lifestyle factors, controlled follow-up, and verified user status, the findings remain preliminary.
This is not the end of the melatonin debate —
it’s the beginning of a more rigorous look at a supplement millions rely on.


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